Brucella suis ΔmapB outer membrane vesicles as an acellular vaccine against systemic and mucosal B. suis infection

Description

Florencia Muñoz González and co-authors test, in a 2024 study, tiny shells shed by a pig bacterium as a vaccine base. The bacterium, Brucella suis, causes brucellosis, a disease that spreads to people, and no vaccine protects pigs or people against it. It most often enters through the linings of the mouth and nose. The shells, called outer membrane vesicles, come from the bacterium's outer membrane.

The team made vesicles from the normal bacterium and from a strain lacking one membrane maintenance gene, mapB. Both kinds held about ninety proteins, many known to stimulate immune responses. Injections in mice raised bacterium-specific defenses in the blood. The mutant vesicles raised more, and spleen cells from those mice released stronger alarm signals. Both kinds protected mice against bacteria delivered into the abdomen. The authors see cell-free vesicles as a safe vaccine path.

Catalog record

Source: https://europepmc.org/articles/PMC11788153