TLR10 overexpression modulates immune response in A549 lung epithelial cells challenged with SARS-CoV-2 S and N proteins
Špela Knez, Mojca Narat, Jernej Ogorevc · 2025
Read TLR10 overexpression modulates immune response in A549 lung epithelial cells challenged with SARS-CoV-2 S and N proteins by Špela Knez, Mojca Narat, Jernej Ogorevc (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11788150.txt.
Description
Knez, Narat, and Ogorevc study an immune sensor in lung cells, in work dated twenty twenty-four. Sensors called Toll like receptors spot virus parts and start innate defense. The role of one sensor, TLR10, in COVID infection was poorly known.
The team raised TLR10 levels in human lung cells in the lab. They then exposed the cells to two viral proteins from the COVID virus. Extra TLR10 mostly lowered swelling signals and interferons. It also changed gene activity in immune cells grown alongside. The authors suggest TLR10 may dampen the response, a hint that tuning it could one day affect care.
Catalog record
| CREATOR | Špela Knez, Mojca Narat, Jernej Ogorevc |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |