Benzimidazole resistance-associated mutations improve the in silico dimerization of hookworm tubulin: An additional resistance mechanism
Jan Clyden B. Tenorio, Muhammad Fikri Heikal, Alok Kafle, Prasert Saichua, Sutas Suttiprapa · 2024
Read Benzimidazole resistance-associated mutations improve the in silico dimerization of hookworm tubulin: An additional resistance mechanism by Jan Clyden B. Tenorio, Muhammad Fikri Heikal, Alok Kafle, Prasert Saichua, Sutas Suttiprapa (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11784061.txt.
Description
Jan Tenorio and co-authors test in 2024 whether drug resistance changes in hookworm tubulin also change how its two parts join. Known changes cut how well the drug binds the protein. Whether they also shift the pairing of the two tubulin parts was unknown for soil worms.
Computer models built the worm protein pair and ran quality checks on its fold. Three changes made the pair bind more strongly and hold more stable than the natural form. Two other changes weakened the pair instead. The strong-pair effect may act as an added route to drug resistance, beyond the known binding loss. Motion runs round out the checks.
Catalog record
| CREATOR | Jan Clyden B. Tenorio, Muhammad Fikri Heikal, Alok Kafle, Prasert Saichua, Sutas Suttiprapa |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |