Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration
Jialiu Zeng, Lenny Yi Tong Cheong, Chih Hung Lo · 2025
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Description
Zeng, Cheong, and Lo reviewed treatments for brain inflammation and degeneration driven by obesity in twenty twenty-four. Obesity is a major changeable risk factor for both. Extra fat draws immune cells that release inflammatory signals into the blood, reaching the brain.
The review explains how a leaky gut from disturbed gut microbes worsens the cycle. Inside the brain, inflammation can drive insulin resistance, energy failure in cells, poor waste cleanup, and oxidative stress. These faults harm neurons and can lead to memory decline and movement problems like those in Alzheimer's and Parkinson's diseases. The authors survey remedies: fixing gut imbalance, lifestyle change, dietary supplements, and drugs from natural sources. Their aim is to match treatments to the pathways obesity disrupts.
Catalog record
| CREATOR | Jialiu Zeng, Lenny Yi Tong Cheong, Chih Hung Lo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |