Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective
Didar Murad, Rehan Zafar Paracha, Maryum Nisar · 2025
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Description
Didar Murad, Rehan Zafar Paracha, and Maryum Nisar model how COVID-19 disturbs two linked defense systems in the body. One system, hemostasis, controls bleeding and clotting. The other, the complement system, is part of first-line immunity, and the two talk to each other constantly. Their study, whose head dates it to 2024, builds a math model of both systems and runs it under several conditions.
They simulate plain disease, disease with weakened regulators, and five drug treatments including heparin. Dropping two regulators, complement factor H and C1-inhibitor, sharply raised clotting and inflammation markers in the model. The tested drugs pushed those markers back toward balance. Early action against thrombin and plasmin looked especially helpful. The authors say the model shows how the balance between attack and restraint is kept, and where treatment might restore it.
Catalog record
| CREATOR | Didar Murad, Rehan Zafar Paracha, Maryum Nisar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |