Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency
Jessica Root, Anarmaa Mendsaikhan, Georgia Taylor, Paola Merino, Srijita Nandy, Minzheng Wang, Ludmilla Troiano Araujo, Danny Ryu, Christopher Holler, Bonne M. Thompson, Giuseppe Astarita, Jean-François Blain, Thomas Kukar · 2024
Read Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency by Jessica Root, Anarmaa Mendsaikhan, Georgia Taylor, Paola Merino, Srijita Nandy, Minzheng Wang, Ludmilla Troiano Araujo, Danny Ryu, Christopher Holler, Bonne M. Thompson, Giuseppe Astarita, Jean-François Blain, Thomas Kukar (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11773623.txt.
Description
Jessica Root and twelve co-authors test a rescue plan for brains that lack a key protein, in a 2024 paper. Missing progranulin raises the risk of several brain diseases, among them a form of dementia. The protein is cut inside cell recycling bins into small pieces called granulins. What each piece does on its own has been unclear, with claims pulling both ways.
The team used a virus to add single pieces, or the full protein, into the brains of mice bred to lack it. Each single piece broadly fixed the disease signs. Swollen recycling bins, stray fats and proteins, immune flare-ups, and waste buildup all eased. The pieces homed to the bins in both mouse brain and dish-grown cells. The authors argue the pieces share one helpful job, which makes them candidate drugs.
Catalog record
| CREATOR | Jessica Root, Anarmaa Mendsaikhan, Georgia Taylor, Paola Merino, Srijita Nandy, Minzheng Wang, Ludmilla Troiano Araujo, Danny Ryu, Christopher Holler, Bonne M. Thompson, Giuseppe Astarita, Jean-François Blain, Thomas Kukar |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |