Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome
Min Du, Xinran Liu, Xu Ji, Yue Wang, Xiaodan Liu, Chunfang Zhao, Erhui Jin, Youfang Gu, Hongyu Wang, Feng Zhang · 2025
Read Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome by Min Du, Xinran Liu, Xu Ji, Yue Wang, Xiaodan Liu, Chunfang Zhao, Erhui Jin, Youfang Gu, Hongyu Wang, Feng Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11772193.txt.
Description
Min Du and co-authors published this 2024 study on a plant compound that may protect young pigs from a diarrhea-causing germ. The germ, a toxic form of Escherichia coli, damages the gut lining of piglets and young children alike. With antibiotic resistance rising, feed-based defenses draw growing interest.
Twenty-four weaned piglets were split into four groups, fed plain feed or feed with berberine at two doses, then dosed with the germ or salt water. Berberine lowered blood markers of gut leak and endotoxin in infected piglets. It also kept the gut lining taller and thicker, with more mucus-making cells. The team link the gains to shifts in the gut microbe mix.
Catalog record
| CREATOR | Min Du, Xinran Liu, Xu Ji, Yue Wang, Xiaodan Liu, Chunfang Zhao, Erhui Jin, Youfang Gu, Hongyu Wang, Feng Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |