Kehuang capsule inhibits MAPK and AKT signaling pathways to mitigate CCl4-induced acute liver injury
Qinyu Ni, Jiacheng Lin, Weifan Huang, Liu Yang, Ran Li, Tianzhi Tu, Guangfu He, Yueqiu Gao, Xuehua Sun, Xiaoni Kong, Xiaojun Zhu · 2024
Read Kehuang capsule inhibits MAPK and AKT signaling pathways to mitigate CCl4-induced acute liver injury by Qinyu Ni, Jiacheng Lin, Weifan Huang, Liu Yang, Ran Li, Tianzhi Tu, Guangfu He, Yueqiu Gao, Xuehua Sun, Xiaoni Kong, Xiaojun Zhu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11771260.txt.
Description
Qinyu Ni and co-authors study how Kehuang capsule eases acute liver injury in mice in a 2024 paper. The herbal product is approved in China for liver diseases, but its working paths were unclear.
Mice poisoned with carbon tetrachloride got low or high capsule doses. Treated mice showed lower liver enzyme levels and smaller dead tissue areas. Immune cell influx fell, and three inflammatory signals dropped. Stress damage marks fell while a defense enzyme rose. Cell death counts also dropped, and protective proteins rose. Network analysis tied gains to MAPK and AKT signal paths. The work gives a mechanism base for a traditional liver remedy.
Catalog record
| CREATOR | Qinyu Ni, Jiacheng Lin, Weifan Huang, Liu Yang, Ran Li, Tianzhi Tu, Guangfu He, Yueqiu Gao, Xuehua Sun, Xiaoni Kong, Xiaojun Zhu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |