Significance of HLA-B*15 in three pemphigus patients with rituximab-triggered severe cutaneous drug reactions
Tang Jun-Ting, Tu Ying, Sun Dong-Jie, Nong Xiang, Cao Can, Du Si-Cheng, Cun Yue-Ting, He Li · 2024
Read Significance of HLA-B*15 in three pemphigus patients with rituximab-triggered severe cutaneous drug reactions by Tang Jun-Ting, Tu Ying, Sun Dong-Jie, Nong Xiang, Cao Can, Du Si-Cheng, Cun Yue-Ting, He Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11770582.txt.
Description
Tang Jun-Ting and colleagues published a 2024 report on three patients with pemphigus, a blistering skin disease, who suffered severe drug reactions after treatment with rituximab. The drug has become a main therapy for pemphigus, yet in these patients the original rash exploded into a dangerous reaction after the second infusion.
Gene sequencing of the patients' blood revealed a striking overlap in their immune-system gene profiles, centered on one gene family already tied to severe drug reactions. The authors argue this pattern may flag patients at risk before treatment, and they urge vigilance for such rare but serious reactions.
Catalog record
| CREATOR | Tang Jun-Ting, Tu Ying, Sun Dong-Jie, Nong Xiang, Cao Can, Du Si-Cheng, Cun Yue-Ting, He Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |