NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice
Si-Ting Huang, Zuo-Ming Chen, Zhe Peng, Yu Wang, Fan Yang, Yang Tang, Zi Li, Li Wan · 2025
Read NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice by Si-Ting Huang, Zuo-Ming Chen, Zhe Peng, Yu Wang, Fan Yang, Yang Tang, Zi Li, Li Wan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11758165.txt.
Description
A skin sensor called NLRP3 helps start swelling in the body, so removing it might be expected to calm an itchy skin disease. Si-Ting Huang led a mouse study that found the opposite. Mice lacking the sensor, exposed to a chemical that brings on long-lasting itch, scratched more than normal mice. Their skin showed less of one signal, IL-18, and more of the signals tied to allergy-type responses.
A channel in the nerve cells, TRPA1, also rose and sat closer to a partner receptor. Blocking that channel, or giving the missing IL-18 back, eased the scratching. The team concludes the sensor normally holds this itch pathway in check, in part by keeping IL-18 levels up.
Catalog record
| CREATOR | Si-Ting Huang, Zuo-Ming Chen, Zhe Peng, Yu Wang, Fan Yang, Yang Tang, Zi Li, Li Wan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |