When prenatal infection meets postnatal hyperoxia: Better models for bronchopulmonary dysplasia and its therapeutic approaches
Ying Dong, Annika Leidner, Manuela Marega, Stefano Rivetti, Saverio Bellusci · 2024
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Description
Ying Dong and four co-authors write to the editor in 2024 with a better animal model for a lung disease of early-born babies. More babies born at 22 to 28 weeks now survive, and many develop the chronic lung condition called bronchopulmonary dysplasia. No strong prevention or cure exists, so animal models carry the search for both.
Their model hits the lung twice: infection before birth, then excess oxygen after it. That pairing mirrors the real path of many preterm infants, whose lungs meet germs in the womb and oxygen therapy in the ward. One-hit models miss that sequence. The letter argues the two-hit rodent model tracks the human disease more closely, giving drug tests a fairer proving ground.
Catalog record
| CREATOR | Ying Dong, Annika Leidner, Manuela Marega, Stefano Rivetti, Saverio Bellusci |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |