Parkin deficiency aggravates inflammation-induced acute lung injury by promoting necroptosis in alveolar type II cells
Meiyu Quan, Qiang Guo, Xihua Yan, Chenhua Yu, Linglong Yang, Yuting Zhang, Jiaqi Li, Qiongxia Weng, Bin Liu, Quan Li, Li Dong, Junjie Chen, Zhenkun Lou, Xuru Jin, Chengshui Chen, Jin-San Zhang · 2024
Read Parkin deficiency aggravates inflammation-induced acute lung injury by promoting necroptosis in alveolar type II cells by Meiyu Quan, Qiang Guo, Xihua Yan, Chenhua Yu, Linglong Yang, Yuting Zhang, Jiaqi Li, Qiongxia Weng, Bin Liu, Quan Li, Li Dong, Junjie Chen, Zhenkun Lou, Xuru Jin, Chengshui Chen, Jin-San Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11742354.txt.
Description
Meiyu Quan and fifteen co-authors show that losing a cleanup enzyme turns lung injury deadlier by unleashing a fiery cell death. Their 2024 study uses bacterial toxin to injure mouse lungs, modeling acute lung injury. As dose rose, the enzyme Parkin rose too, tracking a shift from quiet apoptosis to necroptosis, a bursting death that spills inflammation.
Deleting the death's executioner protein protected the lungs strongly. Deleting Parkin did the opposite: injury worsened, necroptosis surged in the lung's type II lining cells, and scarring followed. A drug blocking necroptosis rescued the Parkin-free animals. Tracing marked the type II cells as the critical site. The authors frame Parkin as a brake on inflammatory death in the lung, and its pathway as a treatment target.
Catalog record
| CREATOR | Meiyu Quan, Qiang Guo, Xihua Yan, Chenhua Yu, Linglong Yang, Yuting Zhang, Jiaqi Li, Qiongxia Weng, Bin Liu, Quan Li, Li Dong, Junjie Chen, Zhenkun Lou, Xuru Jin, Chengshui Chen, Jin-San Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |