Manipulation of mitochondrial poly(A) polymerase family proteins in Trypanosoma brucei impacts mRNA termini processing
Clara M. Smoniewski, Poorya Mirzavand Borujeni, Marshall Hampton, Austin Petersen, Sean P. Faacks, Reza Salavati, Sara L. Zimmer · 2024
Read Manipulation of mitochondrial poly(A) polymerase family proteins in Trypanosoma brucei impacts mRNA termini processing by Clara M. Smoniewski, Poorya Mirzavand Borujeni, Marshall Hampton, Austin Petersen, Sean P. Faacks, Reza Salavati, Sara L. Zimmer (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11732105.txt.
Description
Clara Smoniewski and six co-authors probe two tail-adding enzymes in the mitochondria of the sleeping sickness parasite, in a study published in 2023. The enzymes, KPAP1 and KPAP2, attach strings of adenines to the ends of the organelle’s messages. KPAP1 does most of that work; its partner’s role stayed murky.
By raising and lowering each enzyme and reading the messages’ ends, the team traced effects at both tips of the transcripts and along their tails. Protein separation methods also showed the second enzyme riding in large protein complexes. The details matter because trypanosome mitochondria handle their messages in ways unlike our own cells, which makes their enzymes candidate drug targets against a neglected disease.
Catalog record
| CREATOR | Clara M. Smoniewski, Poorya Mirzavand Borujeni, Marshall Hampton, Austin Petersen, Sean P. Faacks, Reza Salavati, Sara L. Zimmer |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |