Protective effects of Mito-TEMPO on ischemia-reperfusion injury in a mouse testicular torsion and detorsion model

Description

Zohreh Mostahsan, Saeed Azizi, Ali Soleimanzadeh, and Ali Shalizar-Jalali test a protective drug in mice with testicular torsion. Their 2024 study models a surgical emergency: the cord twists, blood flow stops, and untwisting restarts it, yet the return of blood itself injures the tissue through oxidative stress. The drug, Mito-TEMPO, targets the cell's power stations where much of that stress arises.

Forty-two male mice were split into seven groups, with twists of a half or full turn, with or without the drug at two doses. The full turn without treatment did the worst damage: more misshapen sperm, more DNA harm, weaker movement, and a gene pattern favoring cell death. The drug reversed much of that pattern at both twist angles, lifting movement, survival, and the fertility index. The authors conclude the drug gives strong protection in this model.

Catalog record

Source: https://europepmc.org/articles/PMC11729104