Immunolocalization of SP22 (Park7) on the human sperm membrane is indicative of live birth
Gary R Klinefelter, Michael P Diamond, Stephen A Krawetz · 2025
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Description
Gary Klinefelter, Michael Diamond, and Stephen Krawetz report, in a 2025 study, that a sperm protein called SP22 may help predict whether a man can father a child. The protein, made from the Park7 gene, was first tied to rat sperm fertility more than twenty years ago.
Using a targeted antibody, the team compared sperm from donors who achieved a live birth with sperm from donors who did not achieve a pregnancy. Levels of the protein were clearly lower in the second group. Parts of the gene also differed between the groups. The authors present the protein as the first sperm marker of this kind shown to track human fertility.
Catalog record
| CREATOR | Gary R Klinefelter, Michael P Diamond, Stephen A Krawetz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |