Novel Lipid Formulation Increases Absorption of Oral Cannabidiol (CBD)
Edward Chesney, Ndabezinhle Mazibuko, Dominic Oliver, Amedeo Minichino, Ayşe Doğa Lamper, Lucy Chester, Thomas J Reilly, Millie Lloyd, Matilda Kråkström, Alex M Dickens, Matej Orešič, Eric Lynch, Gregory Stoloff, Mitul A Mehta, Philip McGuire, Valentina Maggini, Francesca Baratta, Paola Brusa, Fabio · 2024
Read Novel Lipid Formulation Increases Absorption of Oral Cannabidiol (CBD) by Edward Chesney, Ndabezinhle Mazibuko, Dominic Oliver, Amedeo Minichino, Ayşe Doğa Lamper, Lucy Chester, Thomas J Reilly, Millie Lloyd, Matilda Kråkström, Alex M Dickens, Matej Orešič, Eric Lynch, Gregory Stoloff, Mitul A Mehta, Philip McGuire, Valentina Maggini, Francesca Baratta, Paola Brusa, Fabio (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11728838.txt.
Description
Cannabidiol, a compound from cannabis, treats some childhood epilepsies, but the gut absorbs it poorly when swallowed. Chesney and co-authors tested whether a new lipid formulation could raise absorption. In a double-blind crossover study, healthy fasting volunteers took a single large dose of the compound in lipid form or powder form. The team tracked blood levels for two days. A mouse study checked where the compound ended up in the body.
Blood exposure was nine times greater with the lipid form than with the powder. With the powder, absorption tracked levels of certain gut bacteria and bile acids, links that faded with the lipid form. In mice, the lipid form put measurable amounts into every organ checked, while the water form left levels too low to measure. The authors conclude that the lipid carrier improves absorption and steadies it across different gut states.
Catalog record
| CREATOR | Edward Chesney, Ndabezinhle Mazibuko, Dominic Oliver, Amedeo Minichino, Ayşe Doğa Lamper, Lucy Chester, Thomas J Reilly, Millie Lloyd, Matilda Kråkström, Alex M Dickens, Matej Orešič, Eric Lynch, Gregory Stoloff, Mitul A Mehta, Philip McGuire, Valentina Maggini, Francesca Baratta, Paola Brusa, Fabio |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |