Pleozymes: Pleiotropic Oxidized Carbon Nanozymes Enhance Cellular Metabolic Flexibility
Anh T. T. Vo, Karthik Mouli, Anton V. Liopo, Philip Lorenzi, Lin Tan, Bo Wei, Sara A. Martinez, Emily A. McHugh, James M. Tour, Uffaf Khan, Paul J. Derry, Thomas A. Kent · 2024
Read Pleozymes: Pleiotropic Oxidized Carbon Nanozymes Enhance Cellular Metabolic Flexibility by Anh T. T. Vo, Karthik Mouli, Anton V. Liopo, Philip Lorenzi, Lin Tan, Bo Wei, Sara A. Martinez, Emily A. McHugh, James M. Tour, Uffaf Khan, Paul J. Derry, Thomas A. Kent (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11728746.txt.
Description
Anh Vo and co-authors present a 2024 study on tiny carbon particles that act like several enzymes at once. The particles, called pleozymes, are made by harshly oxidizing coconut charcoal into discs a few nanometers wide. They mimic a protective enzyme, recharge a key cell molecule, and process sulfur compounds.
Earlier work showed the particles settle in mitochondria and raise both energy pathways of the cell. Here the team tracked fuel use with labeled glucose. Treated cells made more pyruvate and lactate and burned more fat, lifting total energy output. Levels of one energy carrier rose while its partner held steady. The results frame pleozymes as flexible boosters of cell metabolism, with promise in nerve disease models.
Catalog record
| CREATOR | Anh T. T. Vo, Karthik Mouli, Anton V. Liopo, Philip Lorenzi, Lin Tan, Bo Wei, Sara A. Martinez, Emily A. McHugh, James M. Tour, Uffaf Khan, Paul J. Derry, Thomas A. Kent |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |