Investigating the Potential Effects of 6PPDQ on Prostate Cancer Through Network Toxicology and Molecular Docking
Yuanzhi Song, Wuhong Weng, Shengde Wu, Zeguang Han · 2024
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Description
Yuanzhi Song and co-authors published a study in 2024 on whether a tire-related pollutant might promote prostate cancer. The chemical, shortened to 6PPDQ, forms when tire additives meet air and now shows up widely in daily life. It is known to harm reproduction and blood vessels, but its links to cancer were untested.
The team used network methods to list the chemical's likely protein targets across several databases, finding 239 in all. Ten core targets sat at the center of the web, many tied to growth signaling. Computer docking showed the chemical fits each core target closely. The study is a map for lab work, not proof: it flags pathways that future experiments should check first.
Catalog record
| CREATOR | Yuanzhi Song, Wuhong Weng, Shengde Wu, Zeguang Han |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |