Global Identification of Anti-Melanoma Cellular Targets by Photochemically Induced Coupling of L-Shikonin Reactions on the Surface of Magnetic Particles
Min Li, Wenying Li, Fang Xu, Yiping Pu, Jianguang Li, Maria Manuela Gaspar, Mariana Matias · 2024
Read Global Identification of Anti-Melanoma Cellular Targets by Photochemically Induced Coupling of L-Shikonin Reactions on the Surface of Magnetic Particles by Min Li, Wenying Li, Fang Xu, Yiping Pu, Jianguang Li, Maria Manuela Gaspar, Mariana Matias (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11728473.txt.
Description
Min Li and co-authors present a 2024 journal article on finding the cell targets of L-shikonin, a plant compound that fights melanoma. The compound's anti-tumor effects are known, but its direct targets were not. The team attached the compound to magnetic particles with a light-activated linker, then fished for the proteins it grabs in melanoma cell extract.
Mass spectrometry named three target proteins: RPN1, CPEB4, and HNRNPUL1. Docking software supported the matches. When melanoma cells were treated with the compound for two days, CPEB4 levels fell at the high dose and HNRNPUL1 fell at medium and high doses. The authors link the compound to melanoma markers and pigment cell structures.
Catalog record
| CREATOR | Min Li, Wenying Li, Fang Xu, Yiping Pu, Jianguang Li, Maria Manuela Gaspar, Mariana Matias |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |