Accounting for the Structure–Property Relationship of Hollow-Fiber Membranes in Modeling Hemodialyzer Clearance
Anton Kozmai, Mikhail Poroznyy, Violetta Gil, Dmitrii Butylskii, Dmitry Lopatin, Aleksey Rodichenko, Igor Voroshilov, Artem Mareev, Victor Nikonenko, Johannes Carolus (John) Jansen · 2024
Read Accounting for the Structure–Property Relationship of Hollow-Fiber Membranes in Modeling Hemodialyzer Clearance by Anton Kozmai, Mikhail Poroznyy, Violetta Gil, Dmitrii Butylskii, Dmitry Lopatin, Aleksey Rodichenko, Igor Voroshilov, Artem Mareev, Victor Nikonenko, Johannes Carolus (John) Jansen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11728457.txt.
Description
Anton Kozmai and co-authors built a math model of dialysis machines that respects the structure of their filter membranes. Dialysis demand is rising with kidney disease, and filters made of hollow fibers do the cleaning. Capturing how pore size and layout affect cleaning power is key to better filters, but tracing the exact pore geometry is impractical.
Their model folds membrane traits like porosity and pore arrangement into mass transfer math without needing that exact geometry. It matched experiments on a lab-built dialyzer and on commercial units. The simulations showed surprises: a well-ordered pore system could multiply clearance nearly tenfold, while for random pores a small porosity rise past a threshold sharply lifts clearance. The authors offer two design strategies from these patterns.
Catalog record
| CREATOR | Anton Kozmai, Mikhail Poroznyy, Violetta Gil, Dmitrii Butylskii, Dmitry Lopatin, Aleksey Rodichenko, Igor Voroshilov, Artem Mareev, Victor Nikonenko, Johannes Carolus (John) Jansen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |