Clozapine and Pneumonia: Synthesizing the Link by Reviewing Existing Reports—A Systematic Review and Meta-Analysis
Victor Zhao, Yiting Gong, Naveen Thomas, Soumitra Das, Win Sen Kuan · 2024
Read Clozapine and Pneumonia: Synthesizing the Link by Reviewing Existing Reports—A Systematic Review and Meta-Analysis by Victor Zhao, Yiting Gong, Naveen Thomas, Soumitra Das, Win Sen Kuan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11728434.txt.
Description
Five reviewers examine the link between the antipsychotic drug clozapine and pneumonia, in a 2024 systematic review and meta-analysis. Clozapine works where other drugs fail for hard-to-treat psychosis, yet it carries serious side effects. The team searched five databases for original studies on clozapine users who developed lung infections.
Clozapine users faced a higher pneumonia risk than users of other antipsychotic drugs. Risk rose with other illnesses, higher doses, and added antipsychotic use. The review lays out likely routes: heavy sedation, excess saliva that can slip into the lungs, and drops in infection-fighting blood cells. Even so, clozapine still lowers overall death rates for its patients. The authors press for wider pneumonia vaccination in this group, since uptake is now low. Careful risk checks should guide each prescription, they add.
Catalog record
| CREATOR | Victor Zhao, Yiting Gong, Naveen Thomas, Soumitra Das, Win Sen Kuan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |