Trajectory of Urine Parameters by Adding Herbal Kampo Medicine Goreisan to Tolvaptan in Patients with Congestive Heart Failure
Kota Kakeshita, Teruhiko Imamura, Yuki Hida, Hiroshi Onoda, Tsutomu Koike, Koichiro Kinugawa, Cristian Fiori, Carlos Escobar · 2024
Read Trajectory of Urine Parameters by Adding Herbal Kampo Medicine Goreisan to Tolvaptan in Patients with Congestive Heart Failure by Kota Kakeshita, Teruhiko Imamura, Yuki Hida, Hiroshi Onoda, Tsutomu Koike, Koichiro Kinugawa, Cristian Fiori, Carlos Escobar (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11728423.txt.
Description
Kota Kakeshita and co-authors watch urine chemistry shift when a herbal formula joins a modern diuretic in heart failure, in a 2024 study. Even on today's best therapy, including the water-channel drug tolvaptan, congestion lingers in many patients. The Kampo formula goreisan is gaining attention as an add-on, but its effect on urine salts was unmeasured.
Twenty-one patients already on tolvaptan-based care received goreisan, and their urine was tracked for the first day. Urine concentration fell significantly, potassium and glucose dropped, and volume tended to rise, while sodium excretion held steady. The team also hunted baseline traits predicting a sodium response. The pattern suggests goreisan moves water more than salt, a nuance for dosing.
Catalog record
| CREATOR | Kota Kakeshita, Teruhiko Imamura, Yuki Hida, Hiroshi Onoda, Tsutomu Koike, Koichiro Kinugawa, Cristian Fiori, Carlos Escobar |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |