Heparin Resistance in Patients Receiving Extracorporeal Membrane Oxygenation: A Review
Tatyana Li, Azhar Zhailauova, Aidyn Kuanyshbek, Iwan Wachruschew, Shaimurat Tulegenov, Vitaliy Sazonov, Timur Kapyshev, Holger Thiele, Karim Bendjelid, Pranas Šerpytis, Robertas Stasys Samalavičius · 2024
Read Heparin Resistance in Patients Receiving Extracorporeal Membrane Oxygenation: A Review by Tatyana Li, Azhar Zhailauova, Aidyn Kuanyshbek, Iwan Wachruschew, Shaimurat Tulegenov, Vitaliy Sazonov, Timur Kapyshev, Holger Thiele, Karim Bendjelid, Pranas Šerpytis, Robertas Stasys Samalavičius (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11728406.txt.
Description
Tatyana Li and co-authors review the puzzle of heparin resistance in patients on life-support circulation machines, in this 2024 article. ECMO pumps a patient's blood outside the body through plastic circuits, and heparin is the drug that stops that blood from clotting on contact. In some patients, standard doses simply fail, a dangerous state called heparin resistance, inviting both clots and bleeding.
The field cannot even agree on what counts as resistance: definitions quarrel over dose units and over which blood test measures the drug's effect. The machine itself muddies the picture, coating its surfaces with protein, summoning immune cells, and consuming the blood factor heparin needs as a partner. Another blood protein can also spend heparin on its own account. The review catalogs the mechanisms and pleads for shared definitions, so studies can be compared and treatment made consistent.
Catalog record
| CREATOR | Tatyana Li, Azhar Zhailauova, Aidyn Kuanyshbek, Iwan Wachruschew, Shaimurat Tulegenov, Vitaliy Sazonov, Timur Kapyshev, Holger Thiele, Karim Bendjelid, Pranas Šerpytis, Robertas Stasys Samalavičius |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |