Impact of T Cell Exhaustion and Stroma Senescence on Tumor Cell Biology and Clinical Outcome of Head and Neck Squamous Cell Carcinomas
Lukas A. Brust, Meike Vorschel, Sandrina Körner, Moritz Knebel, Jan Philipp Kühn, Silke Wemmert, Sigrun Smola, Mathias Wagner, Bernhard Schick, Maximilian Linxweiler · 2024
Read Impact of T Cell Exhaustion and Stroma Senescence on Tumor Cell Biology and Clinical Outcome of Head and Neck Squamous Cell Carcinomas by Lukas A. Brust, Meike Vorschel, Sandrina Körner, Moritz Knebel, Jan Philipp Kühn, Silke Wemmert, Sigrun Smola, Mathias Wagner, Bernhard Schick, Maximilian Linxweiler (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11728369.txt.
Description
Lukas A Brust and nine co-authors probe the immune landscape of head and neck cancers, in this 2024 study. These cancers often return and spread, and the newest immune drugs help fewer than a quarter of patients. The team stained tumor samples for signs that immune cells are worn out, and for aging markers in the tissue around the tumor.
Samples came from 116 patients, and the team also checked vitamin D levels and whether the tumor carried the HPV virus. Surprisingly, stronger worn out markers on immune cells went with longer survival, above all in virus positive tumors. Aging markers in the support tissue had no effect on outcome, and neither did vitamin D. The authors name three immune checkpoints as promising targets for this cancer, especially in virus linked cases.
Catalog record
| CREATOR | Lukas A. Brust, Meike Vorschel, Sandrina Körner, Moritz Knebel, Jan Philipp Kühn, Silke Wemmert, Sigrun Smola, Mathias Wagner, Bernhard Schick, Maximilian Linxweiler |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |