Exploring Immune Cell Infiltration and Small Molecule Compounds for Ulcerative Colitis Treatment
Yi Lu, Dongqing Lu, Chujie Li, Luping Chen · 2024
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Description
Yi Lu and co-authors mine gene data for new leads on ulcerative colitis, a long-term bowel disease, in a 2024 study. The disease flares and fades, and its causes stay murky. The team search public colon tissue data for genes that act up in patients and for small drug-like compounds that might calm them.
Two data sets yielded 12 hub genes tied to the disease, most of them drivers of swelling and immune cell movement. Maps of immune cells in the tissue showed more of some T cell types and fewer of others in patients. A drug-matching database pointed to three compounds, among them vorinostat, whose gene effects run against the disease pattern. The hub genes give labs clear targets, and the compounds offer starting points for tests.
Catalog record
| CREATOR | Yi Lu, Dongqing Lu, Chujie Li, Luping Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |