Mechanisms and Therapeutic Potential of Multiple Forms of Cell Death in Myocardial Ischemia–Reperfusion Injury
Shinya Tsurusaki, Eddy Kizana · 2024
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Description
Restoring blood to a starved heart saves muscle yet injures it too, and several scripted forms of cell death drive that injury. Shinya Tsurusaki and Eddy Kizana review those death programs in this 2024 paper. Necrosis was once dismissed as accidental, but some of it runs on molecular rails like ordinary programmed death. Three such routes — necroptosis, ferroptosis, and pyroptosis — draw special focus.
Reperfusion floods tissue with reactive oxygen, the trigger for much of the damage. Dying heart cells then spark inflammation, scarring, and eventual heart failure. Each death route offers drug targets at its control points. Blocking the right route at the right hour could shrink heart attacks' long shadow.
Catalog record
| CREATOR | Shinya Tsurusaki, Eddy Kizana |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |