Circulating B Lymphocyte Subsets in Patients with Systemic Lupus Erythematosus
Joanna Kosałka-Węgiel, Bogdan Jakieła, Radosław Dziedzic, Mamert Milewski, Andżelika Siwiec-Koźlik, Lech Zaręba, Stanisława Bazan-Socha, Marek Sanak, Jacek Musiał, Mariusz Korkosz, Diana Mieliauskaitė · 2024
Read Circulating B Lymphocyte Subsets in Patients with Systemic Lupus Erythematosus by Joanna Kosałka-Węgiel, Bogdan Jakieła, Radosław Dziedzic, Mamert Milewski, Andżelika Siwiec-Koźlik, Lech Zaręba, Stanisława Bazan-Socha, Marek Sanak, Jacek Musiał, Mariusz Korkosz, Diana Mieliauskaitė (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11727997.txt.
Description
Joanna Kosałka-Węgiel and co-authors profile the B cells circulating in lupus patients, comparing quiet periods with flares, in a 2024 study. Lupus is an autoimmune disease where B cells help produce antibodies that attack the body's own tissues. Which B cell families swell or shrink as the disease wakes was poorly mapped. The team studied thirty-five patients, twelve in flare and twenty-three in remission, all meeting current classification criteria.
Blood samples were sorted by flow cytometry into B cell subsets, from naive cells to memory and regulatory types. Activity scores tracked with the share of transitional and regulatory B cells. Other subsets tracked with complement levels, proteins consumed when the immune system attacks. The authors argue these patterns could help doctors read a patient's state and anticipate flares from a blood draw.
Catalog record
| CREATOR | Joanna Kosałka-Węgiel, Bogdan Jakieła, Radosław Dziedzic, Mamert Milewski, Andżelika Siwiec-Koźlik, Lech Zaręba, Stanisława Bazan-Socha, Marek Sanak, Jacek Musiał, Mariusz Korkosz, Diana Mieliauskaitė |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |