BDSF Analogues Inhibit Quorum Sensing-Regulated Biofilm Production in Xylella fastidiosa
Conor Horgan, Clelia Baccari, Michelle O’Driscoll, Steven E. Lindow, Timothy P. O’Sullivan · 2024
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Description
A bacterium called Xylella fastidiosa causes costly plant diseases, from Pierce's disease of grapes to olive quick decline, and it spreads by forming biofilms, slimy layers that help it persist and travel. Conor Horgan and four co-authors test look-alike signal molecules that might jam the bacterium's group coordination in this 2024 paper. The signals normally tell cells when to build the film.
The team made a library of altered copies of the natural signals and screened them on the wild bacterium and on a mutant that can sense but not make the signals. They counted free-floating cells and measured film mass with a dye test. Several copies blocked film building, with results depending on the chemical group attached. The authors say the hits could seed greener ways to control this plant pest.
Catalog record
| CREATOR | Conor Horgan, Clelia Baccari, Michelle O’Driscoll, Steven E. Lindow, Timothy P. O’Sullivan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |