Treatment of Periprosthetic Joint Infection with Intravenous Vancomycin: Do We Hit the Target?
Rasmus Haglund, Ulrika Tornberg, Ann-Charlotte Claesson, Eva Freyhult, Nils P. Hailer · 2024
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Description
Rasmus Haglund and four co-authors check whether antibiotic levels stay on target during treatment of infected artificial joints, in a 2024 study. Vancomycin is a standard drug for these infections, and blood levels are checked against a target range. How often levels miss that range in this setting was unknown.
The cohort covers 108 patients at one center who got the drug by vein after surgery. Of 791 level measurements, only about fifty eight percent fell in the target range. The rest split between too low and too high. Most patients needed at least one dose change, and treatment lasted a median of eight days. Older age and starting kidney function tracked with higher levels. The authors argue dosing in these patients needs close watch.
Catalog record
| CREATOR | Rasmus Haglund, Ulrika Tornberg, Ann-Charlotte Claesson, Eva Freyhult, Nils P. Hailer |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |