Open-Label Clinical Trial on the Impact of Autologous Dendritic Cell Therapy on Albuminuria and Inflammatory Biomarkers (Interleukin-6, Interleukin-10, Tumor Necrosis Factor α) in Diabetic Kidney Disease (DKD)
Jonny, Enda Cindylosa Sitepu, Bhimo Aji Hernowo, Linda Chiuman, I Nyoman Ehrich Lister, Terawan Agus Putranto, Sung-Kun (Sean) Kim · 2024
Read Open-Label Clinical Trial on the Impact of Autologous Dendritic Cell Therapy on Albuminuria and Inflammatory Biomarkers (Interleukin-6, Interleukin-10, Tumor Necrosis Factor α) in Diabetic Kidney Disease (DKD) by Jonny, Enda Cindylosa Sitepu, Bhimo Aji Hernowo, Linda Chiuman, I Nyoman Ehrich Lister, Terawan Agus Putranto, Sung-Kun (Sean) Kim (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11727525.txt.
Description
The authors (2024) tested the patients' own dendritic cells as a treatment for diabetic kidney disease. Dendritic cells steer the immune system, and calming them might quiet the inflammation that scars diabetic kidneys. Sixty-nine outpatients at an army hospital in Indonesia received one injection of their own prepared cells. The team tracked urine protein weekly for four weeks. They also measured kidney function and three inflammation markers at the start and end.
Urine protein fell sharply in the first week, from a median of 250 to 153 milligrams per gram, and stayed lower. One inflammatory marker, TNF-alpha, also dropped. Kidney filtration did not change, and two other markers stayed flat. The authors read the pattern as a calming effect that runs through TNF rather than through the soothing marker IL-10. They present the therapy as a possible add-on, with long-term safety and dosing still to be worked out.
Catalog record
| CREATOR | Jonny, Enda Cindylosa Sitepu, Bhimo Aji Hernowo, Linda Chiuman, I Nyoman Ehrich Lister, Terawan Agus Putranto, Sung-Kun (Sean) Kim |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |