Silencing LY6K Suppresses CD44+ EpCAM+ HCT116 Human Colon Cancer Stem Cells Growth: Insights from In Vitro and In Vivo Evidence
Changhao Fu, Kuiqiao Chen, Jinyue Duan, Kun Liu, Miaomiao Li, Yuanyuan Chen, Zhongyi Cong, Yi Wang, Liudmila V Spirina · 2024
Read Silencing LY6K Suppresses CD44+ EpCAM+ HCT116 Human Colon Cancer Stem Cells Growth: Insights from In Vitro and In Vivo Evidence by Changhao Fu, Kuiqiao Chen, Jinyue Duan, Kun Liu, Miaomiao Li, Yuanyuan Chen, Zhongyi Cong, Yi Wang, Liudmila V Spirina (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11727511.txt.
Description
Changhao Fu and co-authors tested whether silencing a gene called LY6K can slow colon cancer stem cells, in a 2024 study. The gene is switched on at high levels in several cancers and tracks with poor outcomes in colorectal cancer. The team isolated stem-like cells from a human colon cancer line using two surface markers.
The stem-like cells carried abundant LY6K. When the researchers silenced it with RNA interference, the cells divided more slowly, stalled at a checkpoint in the cell cycle, and moved and invaded less. In mice, silencing the gene shrank tumors and extended survival. The authors propose LY6K as a target for wiping out the stem cells that seed relapse.
Catalog record
| CREATOR | Changhao Fu, Kuiqiao Chen, Jinyue Duan, Kun Liu, Miaomiao Li, Yuanyuan Chen, Zhongyi Cong, Yi Wang, Liudmila V Spirina |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |