Prevention of Muscle Atrophy by Low-Molecular-Weight Fraction from Hirsutella sinensis Mycelium
Yi-Wen Chen, Tsung-Ju Li, Li-Ching Wang, Bi-Hua Yang, Yen-Lien Chen, Chin-Chu Chen, Hsin-Tang Lin, Premalatha Balachandran · 2024
Read Prevention of Muscle Atrophy by Low-Molecular-Weight Fraction from Hirsutella sinensis Mycelium by Yi-Wen Chen, Tsung-Ju Li, Li-Ching Wang, Bi-Hua Yang, Yen-Lien Chen, Chin-Chu Chen, Hsin-Tang Lin, Premalatha Balachandran (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11727312.txt.
Description
The authors test whether an extract from the fungus Hirsutella sinensis can protect muscle from wasting. Muscle loss grows more common as populations age, and earlier work hints this fungus fights fatigue, though its active parts stay unclear. The team feeds a water-and-alcohol extract of the fungal threads to mice with acute leg muscle wasting. They also split a water extract into size fractions and test them on muscle cells driven to waste by a steroid drug.
The extract caused no harm, and treated mice showed better muscle endurance and heavier soleus muscle after 14 days. In the cell tests, the smallest and largest fractions raised two muscle genes, Myh2 and Myh7, and lowered two wasting genes. The smallest fraction alone also raised a key muscle protein and suppressed another signal. The authors present this low-weight fraction as a strong candidate for preserving muscle.
Catalog record
| CREATOR | Yi-Wen Chen, Tsung-Ju Li, Li-Ching Wang, Bi-Hua Yang, Yen-Lien Chen, Chin-Chu Chen, Hsin-Tang Lin, Premalatha Balachandran |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |