Role of Microbiota-Derived Hydrogen Sulfide (H2S) in Modulating the Gut–Brain Axis: Implications for Alzheimer’s and Parkinson’s Disease Pathogenesis
Constantin Munteanu, Gelu Onose, Mariana Rotariu, Mădălina Poștaru, Marius Turnea, Anca Irina Galaction, Marta Lualdi · 2024
Read Role of Microbiota-Derived Hydrogen Sulfide (H2S) in Modulating the Gut–Brain Axis: Implications for Alzheimer’s and Parkinson’s Disease Pathogenesis by Constantin Munteanu, Gelu Onose, Mariana Rotariu, Mădălina Poștaru, Marius Turnea, Anca Irina Galaction, Marta Lualdi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11727295.txt.
Description
Constantin Munteanu and co-authors review how a gut-made gas talks to the brain in two diseases, in a 2024 paper. Hydrogen sulfide, made by gut bacteria that eat sulfur, is a signal the body uses in small doses. At those levels it guards the gut wall and calms body-wide inflammation. In flood, from a skewed gut, it can crack the wall and let harm through.
The review ties that flood to early steps in Alzheimer's and Parkinson's disease. Excess gas feeds brain inflammation and glial upset and speeds the pile-up of the very proteins that mark both diseases. Fixes that reset the gut, from diet to live bacteria to stool transfer, may restore the gas balance. The authors frame the gut-brain line as a drug target hiding in plain sight.
Catalog record
| CREATOR | Constantin Munteanu, Gelu Onose, Mariana Rotariu, Mădălina Poștaru, Marius Turnea, Anca Irina Galaction, Marta Lualdi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |