Antibodies Against Anti-Oxidant Enzymes in Autoimmune Glomerulonephritis and in Antibody-Mediated Graft Rejection
Maurizio Bruschi, Giovanni Candiano, Andrea Petretto, Andrea Angeletti, Pier Luigi Meroni, Marco Prunotto, Gian Marco Ghiggeri · 2024
Read Antibodies Against Anti-Oxidant Enzymes in Autoimmune Glomerulonephritis and in Antibody-Mediated Graft Rejection by Maurizio Bruschi, Giovanni Candiano, Andrea Petretto, Andrea Angeletti, Pier Luigi Meroni, Marco Prunotto, Gian Marco Ghiggeri (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11726969.txt.
Description
Bruschi and colleagues review in twenty twenty-four a second wave of antibodies that attack the body's own antioxidant enzymes in kidney disease. In autoimmune kidney inflammation, oxidants were long suspected but never proven as a direct cause. Evidence now shows a key antioxidant enzyme rises in kidney filter cells after the first antibody attack, as a defence.
Later, patients develop antibodies against that very enzyme, found in blood and kidney deposits in two major diseases. Their levels track patient outcomes. A like pattern appears in transplant rejection, with antibodies against a related enzyme. The authors propose antioxidant molecules, many from diets, to restore balance, noting success in animal models.
Catalog record
| CREATOR | Maurizio Bruschi, Giovanni Candiano, Andrea Petretto, Andrea Angeletti, Pier Luigi Meroni, Marco Prunotto, Gian Marco Ghiggeri |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |