Genetic Variation in Targets of Antidiabetic Drugs and Amyotrophic Lateral Sclerosis Risk
Mengxia Wan, Linjing Zhang, Junyan Huo, Yu Fu, Tao Huang, Dongsheng Fan · 2024
Read Genetic Variation in Targets of Antidiabetic Drugs and Amyotrophic Lateral Sclerosis Risk by Mengxia Wan, Linjing Zhang, Junyan Huo, Yu Fu, Tao Huang, Dongsheng Fan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11726913.txt.
Description
Diabetes drugs have been linked to motor neuron disease in past reports, but those reports can mislead. Mengxia Wan and co-authors used gene tools to test cause rather than mere link, in a 2024 study. Their method treats gene variants in drug targets as stand-ins for taking the drug. Data came from large gene studies with over twenty-seven thousand patients with the disease.
One drug class target, tied to a newer sugar-lowering family, tracked with lower disease risk. A classic drug's main target showed no clear link on its own. One part of that drug's action, a cell energy unit, tracked with higher risk instead. Other drug families showed no clear ties. The authors say gene evidence can sort real drug effects from noise.
Catalog record
| CREATOR | Mengxia Wan, Linjing Zhang, Junyan Huo, Yu Fu, Tao Huang, Dongsheng Fan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |