The Dose Rate of Corpuscular Ionizing Radiation Strongly Influences the Severity of DNA Damage, Cell Cycle Progression and Cellular Senescence in Human Epidermoid Carcinoma Cells
Sergey S Soroko, Dmitry V Skamnitskiy, Ekaterina N Gorshkova, Olga M Kutova, Ismail R Seriev, Anna V Maslennikova, Evgeniy L Guryev, Sergey V Gudkov, Vladimir A Vodeneev, Irina V Balalaeva, Natalia Yu Shilyagina, Sung-Kun (Sean) Kim, Stergios Boussios · 2024
Read The Dose Rate of Corpuscular Ionizing Radiation Strongly Influences the Severity of DNA Damage, Cell Cycle Progression and Cellular Senescence in Human Epidermoid Carcinoma Cells by Sergey S Soroko, Dmitry V Skamnitskiy, Ekaterina N Gorshkova, Olga M Kutova, Ismail R Seriev, Anna V Maslennikova, Evgeniy L Guryev, Sergey V Gudkov, Vladimir A Vodeneev, Irina V Balalaeva, Natalia Yu Shilyagina, Sung-Kun (Sean) Kim, Stergios Boussios (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11726848.txt.
Description
Sergey Soroko and ten co-authors show that the rate at which radiation arrives changes how badly it harms cancer cells. Their study was published in twenty twenty-four. Modern therapy uses both slow and fast delivery, but rate effects for particle radiation were unclear.
Human skin cancer cells were exposed at low and high dose rates. At equal total dose, slow delivery killed fewer cells; the half-lethal dose was three times higher than with fast delivery. Fast delivery halted cell division and produced giant cells; slow delivery did not. DNA damage was much greater under fast delivery, likely explaining the split. The findings matter for choosing sources in particle therapy.
Catalog record
| CREATOR | Sergey S Soroko, Dmitry V Skamnitskiy, Ekaterina N Gorshkova, Olga M Kutova, Ismail R Seriev, Anna V Maslennikova, Evgeniy L Guryev, Sergey V Gudkov, Vladimir A Vodeneev, Irina V Balalaeva, Natalia Yu Shilyagina, Sung-Kun (Sean) Kim, Stergios Boussios |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |