Characterization of a Cancer-Induced Bone Pain Model for Use as a Model of Cancer Cachexia
Takuya Hasegawa, Kohichi Kawahara, Koji Sato, Yoshihisa Asano, Takehiko Maeda · 2024
Read Characterization of a Cancer-Induced Bone Pain Model for Use as a Model of Cancer Cachexia by Takuya Hasegawa, Kohichi Kawahara, Koji Sato, Yoshihisa Asano, Takehiko Maeda (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11726747.txt.
Description
Takuya Hasegawa and four co-authors set up a mouse model that serves two cancer syndromes at once in a 2024 paper. Cancer cachexia wastes muscle and fat and saps strength, and good animal models for testing treatments are scarce. Cancer-induced bone pain, by contrast, is well modeled. The team injected lung cancer cells into the thigh bone of mice, the standard pain model, then checked whether cachexia features followed.
The features did follow. The mice lost weight, muscle, and fat, hurt at the tumor site, and showed anxiety-like behavior. Pain and mood, usually studied apart from wasting, appeared inside one model. The authors offer the setup as a platform for cachexia research that honors its physical and psychological sides together, and for screening therapies against both.
Catalog record
| CREATOR | Takuya Hasegawa, Kohichi Kawahara, Koji Sato, Yoshihisa Asano, Takehiko Maeda |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |