Effects of therapy in experimental models of Peyronie’s disease: a scoping review
Majken Højrup Wiborg, Rasmus Krøijer, Birgitte Schantz Laursen, Lars Lund · 2024
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Description
Peyronie's disease bends the penis through fibrous plaque, and its root causes stay murky despite centuries of notice. Majken Højrup Wiborg and co-authors mapped what lab studies have tried against it in this 2024 scoping review. They screened hundreds of papers and kept forty studies run in animals or in cells.
Two treatment families stood out: erection drugs used for their side effects on tissue, and stem cell therapies. Both cut the proteins of scar tissue and the activity of scar-forming cells, above all in early-stage models. No study followed the standard reporting rules for animal work, a gap the authors flag. They urge better reporting, smarter timing, and combination treatments before human trials can build on the lab work.
Catalog record
| CREATOR | Majken Højrup Wiborg, Rasmus Krøijer, Birgitte Schantz Laursen, Lars Lund |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |