Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy
Min Shi, Yingxi Yang, Na Huang, Dongqiang Zeng, Zongchao Mo, Jiao Wang, Xiaomeng Zhang, Ran Liu, Chunlin Wang, Xiaoxiang Rong, Zhenzhen Wu, Qiong Huang, Haixia Shang, Jihong Tang, Zhaojun Wang, Jianan Cai, Genjie Huang, Yijin Guan, Jian Guo, Quanhua Mu, Jiguang Wang, Wangjun Liao · 2024
Read Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy by Min Shi, Yingxi Yang, Na Huang, Dongqiang Zeng, Zongchao Mo, Jiao Wang, Xiaomeng Zhang, Ran Liu, Chunlin Wang, Xiaoxiang Rong, Zhenzhen Wu, Qiong Huang, Haixia Shang, Jihong Tang, Zhaojun Wang, Jianan Cai, Genjie Huang, Yijin Guan, Jian Guo, Quanhua Mu, Jiguang Wang, Wangjun Liao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11722126.txt.
Description
Min Shi and a large team trace how colorectal cancer liver metastases evolve under chemotherapy, in this 2024 Europe PMC paper. Drug resistance limits treatment success, but how tumors and their surroundings change during therapy was poorly known. The team gathered multi-omics and response data from more than one hundred samples of forty-nine patients on bevacizumab-based treatment.
Genomic changes were small in most cases, while gene activity shifted markedly. Infiltration by liver cells and myeloid immune cells explained much of the acquired resistance. Mutations in SMAD4 and a gain on chromosome arm 20q marked tumors resistant from the start. Blocking STAT3 signaling restored drug response in resistant cells, a possible new combination strategy.
Catalog record
| CREATOR | Min Shi, Yingxi Yang, Na Huang, Dongqiang Zeng, Zongchao Mo, Jiao Wang, Xiaomeng Zhang, Ran Liu, Chunlin Wang, Xiaoxiang Rong, Zhenzhen Wu, Qiong Huang, Haixia Shang, Jihong Tang, Zhaojun Wang, Jianan Cai, Genjie Huang, Yijin Guan, Jian Guo, Quanhua Mu, Jiguang Wang, Wangjun Liao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 106 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |