Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors
Esra Karakose, Xuedi Wang, Peng Wang, Saul Carcamo, Deniz Demircioglu, Luca Lambertini, Olivia Wood, Randy Kang, Geming Lu, Donald K. Scott, Adolfo Garcia-Ocaña, Carmen Argmann, Robert P. Sebra, Dan Hasson, Andrew F. Stewart · 2024
Read Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors by Esra Karakose, Xuedi Wang, Peng Wang, Saul Carcamo, Deniz Demircioglu, Luca Lambertini, Olivia Wood, Randy Kang, Geming Lu, Donald K. Scott, Adolfo Garcia-Ocaña, Carmen Argmann, Robert P. Sebra, Dan Hasson, Andrew F. Stewart (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11722108.txt.
Description
Karakose leads a large team probing how regenerative drugs might rebuild insulin-producing cells in a 2024 paper. Diabetes follows from having too few beta cells, and no approved therapy restores them. Drugs blocking an enzyme called DYRK1A can push beta cells to copy themselves.
Human pancreatic islets were treated with such a drug, alone or paired with partner drugs. Single-cell sequencing showed cycling alpha cells responding most strongly. Path analyses suggested these alpha cells may convert into beta cells along the way. Treated beta cells also raised their identity genes. The authors say the drugs may work partly by recruiting alpha cells as progenitors. The mechanism was unclear until now.
Catalog record
| CREATOR | Esra Karakose, Xuedi Wang, Peng Wang, Saul Carcamo, Deniz Demircioglu, Luca Lambertini, Olivia Wood, Randy Kang, Geming Lu, Donald K. Scott, Adolfo Garcia-Ocaña, Carmen Argmann, Robert P. Sebra, Dan Hasson, Andrew F. Stewart |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |