Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity
Alex L. Roederer, Yi Cao, Kerri St. Denis, Maegan L. Sheehan, Chia Jung Li, Evan C. Lam, David J. Gregory, Mark C. Poznansky, A. John Iafrate, David H. Canaday, Stefan Gravenstein, Wilfredo F. Garcia-Beltran, Alejandro B. Balazs · 2024
Read Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity by Alex L. Roederer, Yi Cao, Kerri St. Denis, Maegan L. Sheehan, Chia Jung Li, Evan C. Lam, David J. Gregory, Mark C. Poznansky, A. John Iafrate, David H. Canaday, Stefan Gravenstein, Wilfredo F. Garcia-Beltran, Alejandro B. Balazs (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11722104.txt.
Description
Alex Roederer and colleagues show how new coronavirus variants escape vaccine immunity. Their study from twenty twenty-four builds a panel of test viruses. Each test virus carries a single spike mutation from the pandemic years. That design isolates the cost and benefit of every mutation.
Fifty variants and well over one hundred mutants were constructed. Later variants steadily resisted vaccine-driven antibody attack better. Infectivity and cell-entry binding rose along the same timeline. A recent booster raised defences against most variants tested. Three newer variants still escaped that booster noticeably. The authors argue vaccines must keep chasing viral evolution. Mutation-by-mutation maps help choose which updates matter most.
Catalog record
| CREATOR | Alex L. Roederer, Yi Cao, Kerri St. Denis, Maegan L. Sheehan, Chia Jung Li, Evan C. Lam, David J. Gregory, Mark C. Poznansky, A. John Iafrate, David H. Canaday, Stefan Gravenstein, Wilfredo F. Garcia-Beltran, Alejandro B. Balazs |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 107 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |