Long-term clinical and safety outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic thoracic spinal cord injury
Joel R Martin, Daniel Cleary, Mickey E Abraham, Michelle Mendoza, Betty Cabrera, Catriona Jamieson, Martin Marsala, Joseph D Ciacci · 2024
Read Long-term clinical and safety outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic thoracic spinal cord injury by Joel R Martin, Daniel Cleary, Mickey E Abraham, Michelle Mendoza, Betty Cabrera, Catriona Jamieson, Martin Marsala, Joseph D Ciacci (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11722094.txt.
Description
Joel Martin and co-authors reported five year results in 2024 from an early trial of human neural stem cells. The cells were placed into the injured spinal cords of four people with long standing chest level injuries. Such trials must first prove the graft is safe before any hope of repair can be weighed.
All four patients tolerated the surgery well over the long follow up. Two showed lasting, measurable gains: electrical tests found new muscle signals, and their movement and feeling scores rose. The study was small and had no comparison group, so it cannot prove the cells caused the gains. But the safety record at five years clears a path for larger trials.
Catalog record
| CREATOR | Joel R Martin, Daniel Cleary, Mickey E Abraham, Michelle Mendoza, Betty Cabrera, Catriona Jamieson, Martin Marsala, Joseph D Ciacci |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |