Selective HDAC8 inhibition by PCI-34051 attenuates inflammation and airway remodeling in asthma via miR-381-3p-TGFβ3 axis
Shiyao Bai, Xinming Su, Delei Kong, Chenye Feng, Xiaochun Zhang, Ying Pan, Jieyu Zhao, Jiamin Sun, Wenyang Li · 2025
Read Selective HDAC8 inhibition by PCI-34051 attenuates inflammation and airway remodeling in asthma via miR-381-3p-TGFβ3 axis by Shiyao Bai, Xinming Su, Delei Kong, Chenye Feng, Xiaochun Zhang, Ying Pan, Jieyu Zhao, Jiamin Sun, Wenyang Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11720934.txt.
Description
Shiyao Bai and co-authors show that blocking one gene silencing enzyme calms asthma in mice, in a 2024 study. The enzyme family trims chemical tags on the proteins that spool DNA, and its role in asthma deserved a closer look. A selective blocker for the eighth family member was the test tool.
Treated mice showed less airway twitchiness, fewer inflammatory signals, and less wall remodeling than untreated asthmatic mice. The blocker raised a small RNA that in turn lowered a growth factor. Silencing that factor then quieted several downstream pathways. The chain gives drug hunters a fresh axis to target in asthma care.
Catalog record
| CREATOR | Shiyao Bai, Xinming Su, Delei Kong, Chenye Feng, Xiaochun Zhang, Ying Pan, Jieyu Zhao, Jiamin Sun, Wenyang Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |