The atrophy of specific amygdala subnuclei is associated with temporal tauopathy in preclinical AD individuals
Yasmine Salman, Thomas Gérard, Lara Huyghe, Lise Colmant, Lisa Quenon, Vincent Malotaux, Emilien Boyer, Adrian Ivanoiu, Renaud Lhommel, Laurence Dricot, Bernard J Hanseeuw · 2025
Read The atrophy of specific amygdala subnuclei is associated with temporal tauopathy in preclinical AD individuals by Yasmine Salman, Thomas Gérard, Lara Huyghe, Lise Colmant, Lisa Quenon, Vincent Malotaux, Emilien Boyer, Adrian Ivanoiu, Renaud Lhommel, Laurence Dricot, Bernard J Hanseeuw (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716977.txt.
Description
Yasmine Salman and co-authors ask whether shrinkage in small parts of the brain's fear center can flag the earliest stage of Alzheimer's disease. In this disease, a harmful protein builds up first in the inner temporal lobe. New scan software can now split that region into fine subparts in living people.
The team studied 144 adults who had the disease's marker protein but still thought normally. Each had a detailed brain scan and a scan for the harmful protein. They asked which subparts' shrinkage best tracked the protein signal. Certain small zones of the fear center and memory hub stood out. A cheap structural scan might one day flag risk before symptoms start. That would help trials recruit the right people early.
Catalog record
| CREATOR | Yasmine Salman, Thomas Gérard, Lara Huyghe, Lise Colmant, Lisa Quenon, Vincent Malotaux, Emilien Boyer, Adrian Ivanoiu, Renaud Lhommel, Laurence Dricot, Bernard J Hanseeuw |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |