Physical activity and diet modify the sex specific association between neurotrophin single nucleotide polymorphisms and insomnia in late‐life
Hector L Gonzalez, Sarah Schwartz, Gail B Rattinger, Yin Liu, Mikaela Drewel, Maddy Mills, Mona Buhusi, JoAnn T Tschanz · 2025
Read Physical activity and diet modify the sex specific association between neurotrophin single nucleotide polymorphisms and insomnia in late‐life by Hector L Gonzalez, Sarah Schwartz, Gail B Rattinger, Yin Liu, Mikaela Drewel, Maddy Mills, Mona Buhusi, JoAnn T Tschanz (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716939.txt.
Description
Hector Gonzalez and seven co-authors studied genes, lifestyle, and sleep in older adults in a 2025 paper. Broken sleep affects up to half of older Americans. The team asked whether variants in genes for a brain growth factor and its receptors relate to insomnia, and whether diet and exercise change that link, in men and women separately.
The data came from a long-running county study with over four thousand healthy older adults. About thirty-nine percent reported insomnia. Four gene variants were tested against sleep trouble in models split by sex. Reported diet followed a Mediterranean pattern score, and activity ranged from none to vigorous. Other factors, like age, weight, schooling, and mood, were held steady in the math. The study design shows how genes and daily habits may combine, differently in each sex, to shape sleep in late life.
Catalog record
| CREATOR | Hector L Gonzalez, Sarah Schwartz, Gail B Rattinger, Yin Liu, Mikaela Drewel, Maddy Mills, Mona Buhusi, JoAnn T Tschanz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |