Longitudinal beta‐amyloid measured with [C‐11]PiB accumulates at an accelerated rate in Down syndrome compared to neurotypical populations
Andrew K McVea, Alexandra H DiFilippo, Max McLachlan, Brecca Bettcher, Matthew D Zammit, Tobey J Betthauser, Alexander K Converse, Dhanabalan Murali, Charles K Stone, Sigan L Hartley, Sterling C Johnson, Dana Tudorascu, Charles M Laymon, Annie Cohen, Davneet S Minhas, Chester Mathis, Beau Ances, Sha · 2025
Read Longitudinal beta‐amyloid measured with [C‐11]PiB accumulates at an accelerated rate in Down syndrome compared to neurotypical populations by Andrew K McVea, Alexandra H DiFilippo, Max McLachlan, Brecca Bettcher, Matthew D Zammit, Tobey J Betthauser, Alexander K Converse, Dhanabalan Murali, Charles K Stone, Sigan L Hartley, Sterling C Johnson, Dana Tudorascu, Charles M Laymon, Annie Cohen, Davneet S Minhas, Chester Mathis, Beau Ances, Sha (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716937.txt.
Description
People with Down syndrome carry an extra copy of the gene for the protein that seeds Alzheimer's plaques. So the sticky protein, beta-amyloid, builds up early in their brains. Andrew McVea and co-authors track how fast it grows in this 2025 study. They use repeated brain scans in fifty-seven adults with the syndrome and one hundred and sixty-two typical adults, some followed for over a decade.
The scans use a tracer that sticks to amyloid. That lets the team measure plaque load year by year in the same people. Accumulation ran faster in the Down syndrome group than in the comparison group. Knowing the pace matters for timing prevention trials in a population where Alzheimer's is common and arrives young. The work rests on one of the largest long-running scan collections of its kind for this group.
Catalog record
| CREATOR | Andrew K McVea, Alexandra H DiFilippo, Max McLachlan, Brecca Bettcher, Matthew D Zammit, Tobey J Betthauser, Alexander K Converse, Dhanabalan Murali, Charles K Stone, Sigan L Hartley, Sterling C Johnson, Dana Tudorascu, Charles M Laymon, Annie Cohen, Davneet S Minhas, Chester Mathis, Beau Ances, Sha |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |