Hypothalamic substructural integrity is associated with age, sex and cognitive function across lifespan: A comparative analysis of two large population‐based cohort studies
Peng Xu, Santiago Estrada, Rika Etteldorf, Dan Liu, Mohammad Shahid, Deborah Frueh, Martin Reuter, Monique MB Breteler, N Ahmad Aziz · 2025
Read Hypothalamic substructural integrity is associated with age, sex and cognitive function across lifespan: A comparative analysis of two large population‐based cohort studies by Peng Xu, Santiago Estrada, Rika Etteldorf, Dan Liu, Mohammad Shahid, Deborah Frueh, Martin Reuter, Monique MB Breteler, N Ahmad Aziz (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716898.txt.
Description
Peng Xu and co-authors map a 2025 question about the hypothalamus, the small brain region that keeps body balance and helps guide thinking. Little was known about how its parts change with age and sex, or how those changes relate to mental scores across a whole life.
The team combined two huge population studies, one in Germany and one in Britain, with tens of thousands of brain scans between them. A new automated tool measured the region's parts from each scan. The authors then tested how size varied with age and sex and how it lined up with test scores. Such maps give a base for spotting when change in this region is not normal.
Catalog record
| CREATOR | Peng Xu, Santiago Estrada, Rika Etteldorf, Dan Liu, Mohammad Shahid, Deborah Frueh, Martin Reuter, Monique MB Breteler, N Ahmad Aziz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |