Locus Coeruleus Neuroimaging compared Voxel by Voxel to Histology‐ a postmortem human validation study
Tia LaMore, Shuo Huang, Pedro Burlacchini S Marinho, Yuheng Chen, Song Hua Li, Wing Hung Lee, Luzia Lima Carreira, Roberta Diehl Rodriguez, Maria Concepción Gracía Otaduy, Yonggang Shi, Lea T Grinberg · 2025
Read Locus Coeruleus Neuroimaging compared Voxel by Voxel to Histology‐ a postmortem human validation study by Tia LaMore, Shuo Huang, Pedro Burlacchini S Marinho, Yuheng Chen, Song Hua Li, Wing Hung Lee, Luzia Lima Carreira, Roberta Diehl Rodriguez, Maria Concepción Gracía Otaduy, Yonggang Shi, Lea T Grinberg (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716882.txt.
Description
Tia LaMore and ten co-authors checked brain scans of a tiny alert hub against the real tissue in a 2025 study. The hub, the locus coeruleus, shrinks early in Alzheimer's disease, about eight percent per stage. If scans could size it well, doctors could track the disease before signs show. Its small size and deep spot make scans prone to error, though.
They scanned three donor brains after death on a strong machine, then rebuilt the hub from tissue slices in 3D. Match scores for the brain stem ran high. Yet the scan outlines caught only a small share of the true hub, from a few percent to under a quarter. The authors say scan sizing of this hub needs much more work.
Catalog record
| CREATOR | Tia LaMore, Shuo Huang, Pedro Burlacchini S Marinho, Yuheng Chen, Song Hua Li, Wing Hung Lee, Luzia Lima Carreira, Roberta Diehl Rodriguez, Maria Concepción Gracía Otaduy, Yonggang Shi, Lea T Grinberg |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |