Extended Exposure to Alzheimer's Risk Factors Increases Alzheimer's Diagnosis Risk Amplified in APOε4 Carriers: Implication for Delayed Onset of Alzheimer's Risk Factors
Simona Merlini, Francesca Vitali, Roberta Diaz Brinton · 2025
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Description
Simona Merlini, Francesca Vitali, and Roberta Diaz Brinton study how long risk factors last before Alzheimer's disease in a 2025 paper. The risk factors are weight gain, diabetes, high blood pressure, high blood fats, and low mood. The team used long-term records from the UK Biobank.
Risk rose with longer exposure, and the gene form APOE4 made the effect stronger. Timing mattered: high blood pressure and diabetes found before age sixty-two raised risk more than the gene did. Weight gain found in midlife nearly tripled risk in one age band. The findings support acting early on these health risks, not waiting until late life.
Catalog record
| CREATOR | Simona Merlini, Francesca Vitali, Roberta Diaz Brinton |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |