Longitudinal neurodegeneration in relation to amyloid pathology among cognitively unimpaired individuals
Henry Gilreath Stephenson, Tobey J. Betthauser, Carol A. Van Hulle, Lianlian Du, Rebecca E. Langhough, Erin M. Jonaitis, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Nathaniel A. Chin, Ozioma C Okonkwo, Cynthia M. Carlsson, Sanjay Asthana, Bradley T. Christian, Sterling C. Johnson, Kaj Blennow, Henrik · 2025
Read Longitudinal neurodegeneration in relation to amyloid pathology among cognitively unimpaired individuals by Henry Gilreath Stephenson, Tobey J. Betthauser, Carol A. Van Hulle, Lianlian Du, Rebecca E. Langhough, Erin M. Jonaitis, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Nathaniel A. Chin, Ozioma C Okonkwo, Cynthia M. Carlsson, Sanjay Asthana, Bradley T. Christian, Sterling C. Johnson, Kaj Blennow, Henrik (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716864.txt.
Description
Henry Stephenson and co-authors tracked brain shrinkage in 2025 among older adults who still think normally, asking when it starts relative to Alzheimer's amyloid. They followed 297 people in Wisconsin studies with repeated brain scans, spinal fluid tests, and amyloid imaging. Groups were sorted by fluid markers of amyloid and tau, and by how long amyloid had been detectable on scans.
Fluid amyloid alone, without a positive scan, showed no clear shrinkage. Once scans turned positive, shrinkage appeared in memory regions, and it was widest in those positive longest. The authors conclude that brain loss begins soon after amyloid becomes scan-visible. Treatment may need to start at that first sign.
Catalog record
| CREATOR | Henry Gilreath Stephenson, Tobey J. Betthauser, Carol A. Van Hulle, Lianlian Du, Rebecca E. Langhough, Erin M. Jonaitis, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Nathaniel A. Chin, Ozioma C Okonkwo, Cynthia M. Carlsson, Sanjay Asthana, Bradley T. Christian, Sterling C. Johnson, Kaj Blennow, Henrik |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |